Internet message boards on the topic of depression are teeming with posts from individuals whom selective serotonin reuptake inhibitor (SSRI) and serotonin norepinephrine reuptake inhibitor (SNRI) antidepressants have not worked for ? finally they have found a medication that has relieved their moderate to severe depression symptoms: Lamictal (lamotrigine), a medication that has been used to treat depression occurring in individuals with Bipolar II Disorder for many years.